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How should I take Glyburide?

Glyburide comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take glyburide twice a day. Take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glyburide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of glyburide and gradually increase your dose if needed. After you have taken glyburide for some time, it may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Glyburide helps control blood sugar but does not cure diabetes. Continue to take it even if you feel well. Do not stop taking glyburide without talking to your doctor.

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Glyburide Side Effects

The common side effects don’t need medical attention and will disappear as your body adjusts to the dosage. But if you are facing any serious or rare side effects, then immediately seek medical attention.

• Angioedema
• Urticaria
• Rash
• Morbilliform eruptions
• Pruritus
• Photosensitivity reaction
• Heartburn
• Vasculitis
• Disulfiram-like reaction
• Hyponatremia
• Nocturia
• Agranulocytosis
• Hemolytic anemia
• Pancytopenia
• Thrombocytopenia
• Porphyria cutanea tarda
• Arthralgia
• Paresthesia
• Myalgia
• Blurred vision
• Diuretic effect (minor)
• Hypoglycemia
• Nausea/vomiting
• Cholestatic jaundice and hepatitis, which occur only rarely, may progress to liver failure
• Weight gain
• Bullous reactions, erythema multiforme, and exfoliative dermatitis

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What Are Warnings and Precautions for Glyburide?

Warnings

Risk of hypoglycemia increases when caloric intake is deficient, when more than one glucose-lowering agent used, when ethanol is ingested, or after severe or prolonged exercise; hypoglycemia is also morelikely to occur in elederly patients, malnourished or debilitated patients, and in patients with adrenal and/or pituitary insufficiency, and patients with severe hepatic and hepatic impairment

Concerns for cross-reactivity between agents containing sulfonamide products has been reported for patients with prior allergic reactions to any compound with the sulfonamide structure SO2NH2; an expanding understanding of allergic mechanisms suggest that cross-reactivity between antibiotic sulfonamides and nonantibiotic sulfonamides may not occur or at the very least the potential is extremely low

Administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin; latest studies, however, do not support association.

Hemolytic anemia may occur with glucose 6-phosphate dehydrogenase (G6PD) deficiency when treated with sulfonylurea agents; use caution and consider a nonsulfonylurea alternative in patients with G6PD deficiency.

More Warnings

There are no clinical studies establishing conclusive evidence of macrovascular risk reduction with anti-diabetic drugs.

It is not recommended in chronic kidney disease; metabolism and excretion of glyburide may be slowed in aptients with renal impairment and its active metabolites, causing accumulation in advanced renal insufficiency; prolonged hypoglycemia could occur

It may be necessary to discontinue therapy and administer insulin if patient exposed to stress.

Micronized tablet formulation is not bioequivalent to conventional glyburide tablets; when transferring patient to a different this medicine formulation, retitrate the dose.

Beta cell destruction may occur following prolonged use of therapy, which may result in loss of treatment efficacy in type 2 diabetes mellitus; discontinue therapy if loss of efficacy occurs in patients who were previously responding to treatment and no contributing factors can be identified.

All sulfonylureas are capable of producing severe hypoglycemia.

Before taking Glyburide, Cautions

Hypersensitivity; sulfa allergy

Type 1 diabetes

Diabetic ketoacidosis with or without coma

Coadministration with bosentan; increased risk of hepatotoxicity

Pregnancy and Lactation

Pregnancy

• Pregnancy category: C

Lactation

• Not known if crosses into breast milk; avoid use in nursing women
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What Are Dosages of Glyburide?

Dosage Forms & Strengths

Glyburide Tablet 1.25mg, 2.5mg, 5mg , Tablet, micronized 1.5mg, 3mg, 5mg and 6mg

20 mg/day PO for conventional glyburide (e.g., Diabeta); 12 mg/day PO for micronized glyburide (e.g., Glynase).

20 mg/day PO for conventional glyburide (e.g., Diabeta); 12 mg/day PO for micronized glyburide (e.g., Glynase).

Safety and efficacy have not been established; off-label use has been reported with a maximum of 10 mg/day PO.

9 years and older: Safety and efficacy have not been established; off-label use has been reported with a maximum of 10 mg/day PO.

1 to 8 years: Safety and efficacy have not been established; off-label use has been reported for selected monogenic diabetes syndromes.

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Glyburide brand name

Glyburide brand name: Diabeta, Glynase, Glynase PresTab

 

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